Since wg-quick doesn't support systemd-resolved, which Fedora 33 have enabled by default, it will fail to set the DNS correctly. I have filed a bug against Fedora 33. https://bugzilla.redhat.com/show_bug.cgi?id=1884352 , but I don't know how responsive they are regarding wireguard so it might be something for you guys to look at. //Mattias